ruppinlab/crispr_risk

The 'crispr_risk' repository is a classic scientific artifact—a code dump intended to support a peer-reviewed publication rather than a maintained software product. With only 2 stars and 0 forks over a 6-year period (2355 days), it shows no evidence of community adoption, developer velocity, or ecosystem integration. The project functions as a reference implementation of a specific methodology for identifying how CRISPR-Cas9 might inadvertently select for p53-mutated cells or other cancer drivers. While the underlying science from the Ruppin Lab is reputable, the software itself lacks any moat; it is easily reproducible by any bioinformatician reading the corresponding paper. In the rapidly evolving field of CRISPR safety, tools like this are quickly superseded by more modern off-target prediction suites (e.g., Guide-seq based tools or newer machine learning models for DNA repair outcomes). There is virtually no risk from frontier labs (OpenAI/Google), as this is a niche biological research tool, but it is effectively 'dead' from a competitive software perspective.