khai-/CoTransFold

CoTransFold addresses a specific limitation in current protein folding models like AlphaFold: the assumption that proteins fold only after being fully synthesized. In reality, proteins begin folding as they emerge from the ribosome (co-translationally), which can lead to different kinetic traps and final structures. While the scientific premise is sound and represents a niche ignored by general-purpose LLM labs, the project currently has 0 stars and no forks, indicating it is in a nascent, 'personal experiment' stage. Its defensibility is low because the code is not yet a community standard and lacks a data moat. Frontier labs are unlikely to compete directly as this is a specialized biophysics problem, but they could absorb the logic into future temporal-aware models. The main competition comes from academic molecular dynamics (MD) suites like GROMACS or specialized research scripts from labs like the Baker Lab (Rosetta). Without a significant user base or validated experimental benchmarks, it remains a high-potential but currently unproven prototype.